Predictors of sustained virologic response in hepatitis C genotype 4: beyond the usual suspects

the correlation of il28b genotype with sustained virologic response in romanian patients with chronic hepatitis c

The Correlation of Il28B Genotype With Sustained Virologic Response In Romanian patients With Chronic Hepatitis C

BACKGROUND Multiple variables influencing the sustained virologic response (SVR) in chronic hepatitis C have been evaluated. One of them is genetic polymorphism near the IL28B gene. OBJECTIVES The aim of this study was to evaluate the influence of IL28B genotypes on SVR rates in a group of patients with chronic hepatitis C from the western part of Romania. PATIENTS AND METHODS A retrospecti...

Durability of Sustained Virologic Response in Chronic Hepatitis C

BACKGROUND/AIMS The aim of this study is to investigate the rate of sustained virologic response (SVR) in chronic hepatitis C patients receiving antiviral treatment. METHODS The files of patients with chronic hepatitis C treated with interferon±ribavirin between 1995 and 2009 were reviewed retrospectively. Six months after the end of treatment, patients with negative hepatitis C virus (HCV)-R...

Hepatitis C Virus Late Relapse after Sustained Virologic Response

24 Hepatitis C (HCV) viremia is unusual (<5%) after successful treatment, defined as sustained 25 virologic response (SVR) or undetectable HCV PCR 12-24 weeks after therapy. We present a 26 case of late virologic relapse (de novo infection excluded by RNA sequencing) after SVR 27 followed by spontaneous viral clearance. 28

Closing in on the target: sustained virologic response in hepatitis C virus genotype 1 infection response-guided therapy.

Retrospective analyses of the boceprevir and telaprevir phase 3 trial data demonstrate the clinical relevance of detected but not quantifiable hepatitis C virus (HCV) genotype 1 RNA during treatment. These analyses illustrate the importance of using precise and standard terminology in reporting low-level HCV RNA results for consistent data collection across clinical trials, and to ensure optima...